Antiphospholipid Profile - APS complete

The Extended antiphospholipid profile (APS) is a comprehensive set of laboratory tests designed to detect autoantibodies and functional hemostatic abnormalities associated with antiphospholipid syndrome. It is used for the diagnosis of immune-mediated thrombophilias, assessment of thrombotic and obstetric risk, and monitoring of confirmed APS.

Indications

• suspicion of antiphospholipid syndrome (APS)
• venous and/or arterial thrombosis
• recurrent pregnancy loss or pregnancy complications
• unexplained infertility
• unexplained thrombophilia
• autoimmune diseases (including systemic lupus erythematosus)
• suspected immune-related coagulation disorders
• monitoring of confirmed APS

Profile components

• Lupus anticoagulant (confirmatory test) - functional coagulation test detecting antiphospholipid antibodies associated with increased thrombotic risk
• Anti-β2-glycoprotein I IgG antibodies - major serological marker of APS associated with thrombotic and obstetric complications
• Anti-β2-glycoprotein I IgM antibodies - marker of early or active immune response
• Anti-cardiolipin IgG antibodies - key diagnostic marker of APS associated with thrombosis and pregnancy complications
• Anti-cardiolipin IgM antibodies - marker of immune activity used in the comprehensive evaluation of APS

Procedure

Venous blood sampling is performed under standard laboratory conditions. For lupus anticoagulant testing, plasma-based coagulation assays are used.